KMID : 1161520010050020139
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Animal Cells and Systems 2001 Volume.5 No. 2 p.139 ~ p.143
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Non-fibrillar ¥â-amyloid exerts toxic effect on neuronal cells
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Kim Hyeon-Jin
Hong Seong-Tshool
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Abstract
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Alzheimer's disease is the most common form of dementia and no cure is known so far. Extensive genetic works and in vitro experiments combined with clinical observations link amyloid ¥â?protein (A¥â) to the pathogenesis of Alzheimer's disease (AD). It was hypothesized that A¥â becomes toxic when it adopts a fibrillar conformation. Recently, non?fibrillar form of A¥â was observed and the potential role in the pathogenesis of AD became an interesting subject. In this study, the cytotoxicity of non?fibrillar A¥â and fibrillar A¥â was compared on oxidative stress, membrane damage, or nucleosome break down. Non?fibrillar A¥â was not toxic in peripheral nervous system?derived cells but significantly toxic in central nervous system?derived cells while fibrillar A¥â was non?selectively toxic in both cell culture. The neurotoxicity of non?fibrillar A¥â was reproduced in semi?in vivo culture of mouse brain slice. In conclusion, non?fibrillar A¥â could be more relevant to the selective neurodegeneration in Alzheimer's brains than fibrillar A¥â and further research needs to be done for identification of the cause of AD.
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KEYWORD
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Alzheimer's disease, ¥â-Amyloid, NT2, SHSY5Y, Slice, Neurotoxicity
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